The increase in HCO 3 results in the stimulation of adenylate cyclase AC which converts adenosine triphosphate ATP to cyclic adenosine monophosphate cAMP. The subsequent binding of cAMP to cAMP-dependent protein kinase A PKA leads to immediate phosphorylation of PK.
G Proteins Adenylate Cyclase Membrane Dissociation System
Thus as has already been mentioned above phosphorylase kinase.
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